In a randomized researched recently conducted on Actinic Keratosis, it has been discovered that Ingenol Mebutate therapy is capable of helping medical experts deal with actinic keratosis much better. As a mater of fact the Ingenol mebutate Gel is ideal for Non-facial Actinic keratoses. According to the research, 222 individuals were subjected to a daily dosage of Ingenol Mebutate at 0.025% IM level and the gel applied once daily for 3 days. This application is then followed by 2 days of applying the same concentration of gel and the treatment was followed up for 57 days from the initial applications. In the course of the treatment, only two subjected dropped out. A control application was also applied.
Results shows that all the regimens of Ingenol Mebutate applied cleared off Actinic Keratosis more effectively than the regimen alone. The percentage of those with partial clearance of actinic keratoses increased in all the groups while those with complete clearance were almost 92% according to the research.
The content of Ingenol Mebutate are derived from the plant- Euphorbia peplus. These ingredients are capable of causing Cellular necrosis alongside some immuno-modulatory on the skin. The report shows that the clearance of the AK by the Ingenol Mebutate is comparable to 5-fluorouracil and Imiquimod. The experiment offers the patients the opportunity to increase their compliance and the downtime can be compared with other topical treatments.
Aside the fact that AK infections in individual sufferers were clearly removed, it was also observed that individuals who received the three-day treatment had a better skin than those who received the treatment for 2 days who in turn had a better skin than those who received the control treatment. In overall, Ingenol mebutate was discovered to possess some skin rejuvenating properties.